Methotrexate Cost

Written by: Staff

Methotrexate, the generic equivalent of Trexall, is a chemotherapy drug used to treat cancers such as breast cancer, leukemia and lymphoma.  It’s also commonly prescribed to help treat psoriasis and certain kinds of arthritis.

How much does Methotrexate cost?

Being a generic prescription, like most generics, the costs of Methotrexate is relatively cheap, even if you do not have health insurance coverage.  Depending on your health insurance coverage, the quantity, the type (tablet vs. injection) and the pharmacy you choose, the costs can greatly vary, but to give you an idea as to what you may pay without insurance, here’s what we found online for the 2.5mg tablets and 25 mg/ml vial (the only dosages available at the time of this publishing):

TypeAverage Price Reported
25 MG/ML Vial- 10 mls: $45
- 20 mls: $85
- 30 mls: $120
2.5 MG Tablet- 30: $60
- 50: $75
- $100: $115

How did we get these numbers?  We called a few of the most popular pharmacies in the area, including CVS, Walgreens, Walmart and Costco to see what the prescription would cost without any health insurance coverage.  With this information, we then compiled the average, which you can see inside of our table above.

Does insurance cover Methotrexate?

Yes, according to multiple resources we viewed online, it appeared that both Medicare and almost all private insurance companies do cover the medication, leaving you responsible for your co-pay/deductible.  While this isn’t 100% certain, talk with your health insurance company or refer to your documentation to know exactly what you may be responsible for.  If you already have a prescription, your local pharmacy will be able to offer you a cost estimate as well as long as you provide them with your health insurance information.

How to save on Methotrexate

Patient assistance program

Multiple assistance programs, ranging from government to non-profits, exist online to help you pay some or even all of your medication costs as long as you qualify.  The Pulmonary Fibrosis Fund and the Systemic Lupus Erythematosus Fund, offered by the HealthWell Foundation, for example, can financially help you out if you have health insurance, meet income requirements and have a valid prescription.  To see if you qualify, visit the link, fill out an application and provide them with the supporting documents to see if you can receive assistance.  This is just one of the many patient assistance programs examples, so it doesn’t hurt to search for programs, specifically for your condition, to see if you can get help.


Third-party prescription coupon websites, such as, can help you save on your prescription, regardless of your circumstances.  These websites are quite simple to use:  simply search for your medication, the dosage you’re prescribed for and print out the coupon for the pharmacy you plan on using.  If you do use this type of coupon, however, you will only be able use either the coupon or your health insurance, not a combination of both.

Methotrexate side effects

As per  John P. Cunha, DO, FACOEP via, side effects of methotrexate may include:

This is not a full list of side effects and others may occur.  Talk with your doctor for more information in regards to side effects you may experience.

What is methotrexate?

Methotrexate tablets are commonly used alone or in combination with other medicines to help treat a variety of cancers, most notably breast, neck, head, lung, bone, blood and uterus, to name a few.  It also can help control the symptoms of rheumatoid arthritis, severe psoriasis in adults and in children, help treat polyarticular juvenile idiopathic arthritis.

Belonging to a group of medicines known as antineoplastics, methotrexate helps block an enzyme which is needed for the cell to live, effectively interfering with the cancer cell growth, eventually becoming destroyed by the body.  For some, it can even help by improving the immune system.

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