How Much Do Synvisc-One® Injections Cost?


Written by:  Howmuchisit.org Staff
Last Updated:  August 10, 2018

Synvisc-One® is an injection which helps supplement the fluid in your knee to help lubricate and cushion the joint, providing up to six months of knee relief, according to the manufacturer.

In knees with osteoarthritis, the joint fluid will break down, not providing the cushioning your knee needs for support and comfort.

This injection, made from a natural substance, known as Hyaluronan, comes from chicken combs and is found in high amounts in the joints.  This gel-like mixture, when injected, allows the body to absorb this natural substance, allowing the knee joint to work the way it should.

Essentially, it acts as a lubricant and shock absorber.

Synvisc-One® Injections Cost
Knees !” (CC BY 2.0) by Ali Smiles 🙂

The reported Synvisc-One® injections cost

The costs of injections will depend on the doctor injecting it and the type of health insurance policy you have.  According to the manufacturer of the drug, Synvisc-One®, Medicare and most health insurance plans will cover the injections, and essentially, you will only be responsible for your co-pays and/or deductibles.  The manufacturer did create a tool to help you determine if your health insurance company will cover the injections.

From those who did have to pay for the injection, whether they had insurance or not, the costs were in the $400 to $1,000 per injection average.  Granted, this price could be much lower, again, if you were to use your health insurance provider.  Even if you paid cash, many providers are willing to offer a discount and/or financing plan if you couldn’t pay the bill in full.

On the comments section for this injection on Drugs.com, multiple people talked about the prices they paid.  One member, who gave the injection, gave it one star and said it was $2,000 for the injection, but Medicare paid for it, and there was no improvement in her pain, according to her review.  Another member stated they were quoted $1,000 a shot and felt no relief from the injections, either.

The providers on MDSave.com quoted close to $750 per knee injection.

In some cases, consumers also reported being able to purchase the injection at a local pharmacy and having their doctor perform the injection.  Without any insurance, a 48mg/6 ml vial, depending on the pharmacy you chose, either online or in person, ranged anywhere from $600 to $1,400.  These prices, again, are for those without insurance, so if you did have it or even had a prescription discount card, the costs could decrease.

BlinkHealth.com, for example, listed multiple pharmacies, with a price averaging about $1,300 for those using their service.

How it’s used

As it can only be prescribed by a doctor, these injections will always be done in the doctor’s office by either a trained health professional, such as an orthopedic surgeon or rheumatologist, or a nurse.

This medicine, injected into the knee joint, will be given as a single injection only, using either an 18- or 20- gauge needle.  Don’t get this confused with Synvisc® as this is a 3-injection regimen and usually given weekly for a total of three injections.  The entire process can be viewed as a guide here or if you prefer, you can watch a video here.

After the injections, you should start feeling relief about 30 days after the injection.  During this time, especially after the injection, your doctor may ask you to rest your knee for a short period of time while using an ice compress.

Side effects

In a medical study, of the 253 patients studied with knee osteoarthritis, the side effects were tracked, which included knee pain, swelling, fluid buildup, and stiffness.  Side effects, as per the study, were deemed mild to moderate and did not last long.


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